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Linxis Group

The DIOSNA glossary


Technological terms in an overview

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Washing-In-Place (WIP)


Automatic pre-cleaning of the plant, followed by a manual final-cleaning where applicable.

Wet granulation


Realisation of a granulation with liquid addition mostly containing binder as additive in a mixer granulator.

Wet milling


Useful process step following a wet granulation for homogenisation of the granules, so that a smooth and efficient drying can be effected.

Wiper


The mixer lid of a mixer-granulator is often equipped with an inspection glass which is provided with a manual wiper to clean the window from product deposits.

WSG


Often used abbreviation for fluid bed granulator.

WST


Often used abbreviation for fluid bed dryer.

Wurster-Process


The so-called Wurster process was developed by Dale E. Wurster at the pharmaceutical institute of the University Wisconsin in 1959. It is a fluid bed bottom spray process to coat tablets, pellets and particles. The Wurster process consists of a material bowl with one or more tubes (Wurster partition) with a spraying nozzle in the middle. A specially designed air distributor plate takes care that the air streams inside the pipe with highest velocity. Because of the low pressure the product is sucked in through a gap between pipe and bottom and is strongly accelerated inside the pipe. In the ideal case there are single particles available which are sprayed through the nozzle. The particles dry in the expansion chamber above the pipes and fall back laterally into the fluid bed. There is a defined product movement which leads to a uniform coating result.

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