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Compass for granulation processes

Solid dosage forms: Multi-step process or single-pot process?

Decision support for selecting the right granulation and drying process, considering various critical material properties, and process requirements. When manufacturing solid dosage forms, such as wet and dry granules for compression, effervescent granules or (micro) pellets for the pharmaceutical, homeopathic and food supplement industries, there are several criteria that are significant when choosing the right manufacturing process. In addition to the requirements for the quality and quantity of the granules and their individual particles, the specific handling requirements of the respective active ingredients and excipients in terms of toxicity, sensitivity to factors such as light, moisture, heat and oxygen play an essential role. Finally, external factors such as budget requirements, space requirements, the need for flexibility regarding product changes and process options, efficiency (downtimes & process speed) and staff availability are also critical. This white paper compares different process options in the context of these various criteria and is intended to provide a decision-making aid for the right manufacturing process. For this purpose, the following process options will be analysed, based on the topic of granulation:

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